Maternal nutrient metabolism in the liver during pregnancy.

The liver plays pivotal roles in nutrient metabolism, and correct hepatic adaptations are required in maternal nutrient metabolism during pregnancy. In this review, hepatic nutrient metabolism, including glucose metabolism, lipid and cholesterol metabolism, and protein and amino acid metabolism, is first addressed. In addition, recent progress on maternal hepatic adaptations in nutrient metabolism during pregnancy is discussed. Finally, the factors that regulate hepatic nutrient metabolism during pregnancy are highlighted, and the factors include follicle-stimulating hormone, estrogen, progesterone, insulin-like growth factor 1, prostaglandins fibroblast growth factor 21, serotonin, growth hormone, adrenocorticotropic hormone, prolactin, thyroid stimulating hormone, melatonin, adrenal hormone, leptin, glucagon-like peptide-1, insulin glucagon and thyroid hormone. Our vision is that more attention should be paid to liver nutrient metabolism during pregnancy, which will be helpful for utilizing nutrient appropriately and efficiently, and avoiding liver diseases during pregnancy.

Efficient CO2 Capture and Separation in MOFs: Effect from Isoreticular Double Interpenetration.

Severe CO2 emissions has posed an increasingly alarming threat, motivating the development of efficient CO2 capture materials, one of the key parts of carbon capture, utilization, and storage (CCUS). In this study, a series of metal-organic frameworks (MOFs) named Sc-X (X = S, M, L) were constructed inspired by recorded MOFs, Zn-BPZ-SA and MFU-4l-Li. The corresponding isoreticular double-interpenetrating MOFs (Sc-X-IDI) were subsequently constructed via the introduction of isoreticular double interpenetration. Grand canonical Monte Carlo (GCMC) simulations were adopted at 298 K and 0.1-1.0 bar to comprehensively evaluate the CO2 capture and separation performances in Sc-X and Sc-X-IDI, with gas distribution, isothermal adsorption heat (Qst), and van der Waals (vdW)/Coulomb interactions. It is showed that isoreticular double interpenetration significantly improved the interactions between adsorbed gases and frameworks by precisely modulating pore sizes, particularly observed in Sc-M and Sc-M-IDI. Specifically, the Qst and Coulomb interactions exhibited a substantial increase, rising from 28.38 and 22.19 kJ mol-1 in Sc-M to 43.52 and 38.04 kJ mol-1 in Sc-M-IDI, respectively, at 298 K and 1.0 bar. Besides, the selectivity of CO2 over CH4/N2 was enhanced from 55.36/107.28 in Sc-M to 3308.61/7021.48 in Sc-M-IDI. However, the CO2 capture capacity is significantly influenced by the pore size. Sc-M, with a favorable pore size, exhibits the highest capture capacity of 15.86 mmol g-1 at 298 K and 1.0 bar. This study elucidated the impact of isoreticular double interpenetration on the CO2 capture performance in MOFs.

Maternal hepatic immunology during pregnancy.

The liver plays pivotal roles in immunologic responses, and correct hepatic adaptations in maternal immunology are required during pregnancy. In this review, we focus on anatomical and immunological maternal hepatic adaptations during pregnancy, including our recent reports in this area. Moreover, we summarize maternal pregnancy-associated liver diseases, including hyperemesis gravidarum; intrahepatic cholestasis of pregnancy; preeclampsia, specifically hemolysis, elevated liver enzymes, and low platelet count syndrome; and acute fatty liver of pregnancy. In addition, the latest information about the factors that regulate hepatic immunology during pregnancy are reviewed for the first time, including human chorionic gonadotropin, estrogen, progesterone, growth hormone, insulin like growth factor 1, oxytocin, adrenocorticotropic hormone, adrenal hormone, prolactin, melatonin and prostaglandins. In summary, the latest progress on maternal hepatic anatomy and immunological adaptations, maternal pregnancy-associated diseases and the factors that regulate hepatic immunology during pregnancy are discussed, which may be used to prevent embryo loss and abortion, as well as pregnancy-associated liver diseases.

Effects of Shale Pore Size and Connectivity on scCO2 Enhanced Oil Recovery: A Molecular Dynamics Simulation Investigation.

The differences in pore width distributions and connectivity of shale reservoirs have significant influences on supercritical carbon dioxide (scCO2)-enhanced oil recovery (CO2 EOR) in shale. Herein, the molecular dynamics simulation was adopted to investigate the microscopic mechanism of CO2 EOR in the shale nanopores with different pore size width distributions and pore connectivity. The results show that the pore connectivity has significant effects on the oil displacement, and the recovery efficiency is ordered as: connected pore > double pore > single pore for the 3 nm pore, which are 91.32, 74.43, and 65.93%, respectively. Therefore, the increase in pore connectivity can significantly improve the recovery efficiency of the small pore of the connected pore system. For the shale reservoirs with different pore width distributions, the oil recovery rate of large pores is generally higher than that of small pores. In addition, the displacement of oil in the small pore of the double pore system is accelerated due to the pushing effect of the discharge fluid from the large pore. The results furnish a certain theoretical support for the research of the microscopic mechanism of CO2 EOR in the shale pore with different pore width distributions and connectivity and the exploit of shale oil.

Early Pregnancy Modulates Expression of the Nod-like Receptor Family in Lymph Nodes of Ewes.

NOD receptors (NLRs) mediate adaptive immune responses and immune tolerance. Nevertheless, it is not clear if gestation modulates the NLR signaling pathway in lymph nodes of ewes. In this study, lymph nodes of ewes were collected at day 16 of the estrous cycle, and at days 13, 16 and 25 of gestation (n = 6 for each group). RT-qPCR, Western blot and immunohistochemistry analysis were used to analyze the expression of the NLR family, including NOD1, NOD2, CIITA, NAIP, NLRP1, NLRP3 and NLRP7. The data showed that early gestation enhanced expression of NOD1, CIITA, NLRP1, NLRP3 and NLRP7 mRNA, as well as proteins at day 16 of gestation, and the expression levels of NOD2, CIITA, NLRP1 and NLRP7 were higher at days 13 and 25 of gestation than day 16 of the estrous cycle. However, NOD1 expression was lower on days 13 and 25 of gestation compared to day 16 of the estrous cycle, and early gestation suppressed NAIP expression. In summary, early pregnancy modulated expression of the NLR family in ovine lymph nodes, which participates in immune regulation, and this modulation may be necessary for pregnancy establishment in ewes.

Molecular Dynamics Insight into the CO2 Flooding Mechanism in Wedge-Shaped Pores.

Because of the growing demand for energy, oil extraction under complicated geological conditions is increasing. Herein, oil displacement by CO2 in wedge-shaped pores was investigated by molecular dynamics simulation. The results showed that, for both single and double wedge-shaped models, pore Ⅱ (pore size from 3 to 8 nm) exhibited a better CO2 flooding ability than pore Ⅰ (pore size from 8 to 3 nm). Compared with slit-shaped pores (3 and 8 nm), the overall oil displacement efficiency followed the sequence of 8 nm > double pore Ⅱ > single pore Ⅱ > 3 nm > double pore Ⅰ > single pore Ⅰ, which confirmed that the exits of the wedge-shaped pores had determinant effects on CO2 enhanced oil recovery over their entrances. "Oil/CO2 inter-pore migration" and "siphoning" phenomena occurred in wedge-shaped double pores by comparing the volumes of oil/CO2 and the center of mass. The results of the interaction and radial distribution function analyses indicate that the wide inlet and outlet had a larger CO2−oil contact surface, better phase miscibility, higher interaction, and faster displacement. These findings clarify the CO2 flooding mechanisms in wedge-shaped pores and provide a scientific basis for the practical applications of CO2 flooding.